Tissue engineering of the meniscus: Scaffolds for meniscus repair and replacement
نویسندگان
چکیده
Department of Medical Microbiology, Immunology & Cell Biology, Southern Illinois University, School of Medicine, Springfield, IL, USA Division of Orthopaedics Surgery, Department of Surgery, Southern Illinois University, School of Medicine, Springfield, IL, USA Department of Electrical and Computer Engineering, Biomedical Engineering Program, Southern Illinois University Carbondale, Carbondale, IL, USA
منابع مشابه
Loop-Post Construct, A Novel Technique for Medial Meniscus Root Repair
Surgical reattachment of medial meniscus posterior root tear (MMPRT) with transtibial sutures can delay the presenceof medial knee joint compartment osteoarthritis. Most suture configurations are placed five mm away from the tornmargin in the meniscal substance which is already degenerated and may decrease the pull out strengths of repairconstruct. The number of meniscus penet...
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Few therapeutic options exist for meniscus repair after injury. Local delivery of growth factors may stimulate repair and create a favorable environment for engineered replacement materials. In this study we assessed the effect of basic fibroblast growth factor (bFGF) (a pro-mitotic agent) and transforming growth factor β3 (TGF-β3) (a pro-matrix formation agent) on meniscus repair and the integ...
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Meniscus degeneration due to age or injury can lead to osteoarthritis. Although promising, current cell-based approaches show limited success. Here we present three-dimensional methacrylated gelatin (GelMA) scaffolds patterned via projection stereolithography to emulate the circumferential alignment of cells in native meniscus tissue. Cultured human avascular zone meniscus cells from normal men...
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Meniscus injuries remain a significant challenge due to the poor healing potential of the inner avascular zone. Following a series of studies and clinical trials, tissue engineering is considered a promising prospect for meniscus repair and regeneration. As one of the key factors in tissue engineering, cells are believed to be highly beneficial in generating bionic meniscus structures to replac...
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The emerging field of tissue engineering holds the promise to use bio-materials for meniscus injury repair, namely scaffold or meniscus implant. Many implants have been studied and several studies have been conducted to verify the safety and quality of scaffolds. Preliminary data support the idea that synthetic implants can provide an alternative to menyscectomy helping to preserve the cartilag...
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